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DULUTH, MN MANILA, PH
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Open Data Library

Free, downloadable, real.

The medical and pharma databases I actually use and trust — every one of them free, every one of them downloadable, every one linked straight to its official source. No mirrors, no paywalls, no "sign up to see pricing." Where a source needs a free account or credentialing, the card says so plainly.

Take the library with you: catalog.json catalog.csv

Drugs & safety

U.S. Food & Drug Administration Direct download

openFDA

FDA public data as JSON APIs and bulk downloads: drug adverse-event reports (FAERS), drug labels, recalls and enforcement actions, device adverse events, and NDC product listings.

Humanity’s most complete public ledger of what happened after we swallowed, injected, or implanted something.

Formats
JSON API · bulk JSON (zipped)
Size
~GBs per endpoint (adverse events are the big one)
License
Public domain (CC0)
Updated
Regularly (endpoint-dependent)

U.S. National Library of Medicine Direct download

DailyMed (SPL drug labels)

The current FDA label (Structured Product Labeling) for essentially every marketed drug in the U.S. — full prescribing information as structured XML, downloadable in bulk.

The fine print of every pill bottle in the country, machine-readable.

Formats
XML (SPL) · bulk ZIP releases · REST API
Size
~145k+ labels; multi-GB in bulk
License
Public domain
Updated
Daily

U.S. Food & Drug Administration Direct download

FDA Orange Book data files

Approved drug products with therapeutic-equivalence evaluations — the authoritative list behind generic substitution, plus patent and exclusivity data, as plain downloadable data files.

The book pharmacists argue with. Now a ZIP file.

Formats
TXT (delimited) in ZIP
Size
~MBs
License
Public domain
Updated
Monthly

DrugBank (University of Alberta / OMx) Free registration required

DrugBank Open Data

The freely licensed subset of DrugBank: the open drug & drug-target vocabulary (identifiers, names, CAS/UNII mappings) released under CC0. The full database requires a license — this subset does not.

Formats
CSV (zipped)
Size
~MBs
License
CC0 1.0 (open subset only)
Updated
With DrugBank releases

U.S. National Library of Medicine Free registration required

RxNorm

The normalized naming system that lets U.S. drug databases talk to each other — every clinical drug, dose form, and brand mapped to stable identifiers. Full monthly releases downloadable with a free UMLS account.

The Rosetta Stone for why your pharmacy’s computer and your hospital’s computer disagree.

Formats
RRF (pipe-delimited) · API (JSON)
Size
~100s of MBs
License
Free; UMLS Metathesaurus License (free account) for full files
Updated
Monthly

Clinical trials

U.S. National Library of Medicine Direct download

ClinicalTrials.gov

The registry and results database of clinical studies conducted around the world — protocols, arms, outcomes, and posted results. Full API (v2) plus complete bulk download of every study record.

Every registered trial since 2000 — including the ones that quietly never enrolled anyone.

Formats
REST API (JSON) · bulk JSON/CSV
Size
~500k+ study records
License
Public domain (U.S. Government work); attribution requested
Updated
Daily

Population health

U.S. Centers for Disease Control and Prevention Direct download

CDC WONDER

Query-and-export access to CDC’s epidemiologic datasets: underlying-cause-of-death mortality, natality, cancer statistics, vaccinations, and more, exportable as delimited text.

Formats
web query → TSV export · API (XML)
Size
Query-sized slices of very large collections
License
Public domain (data-use restrictions on small cells)
Updated
Dataset-dependent (mortality: annually + provisional)

CDC / National Center for Health Statistics Direct download

NHANES

The National Health and Nutrition Examination Survey — interviews, physical exams, and lab measurements on a representative sample of the U.S. population, in continuous cycles since 1999.

The reason we know what the average American’s cholesterol actually is.

Formats
SAS transport (.XPT) · CSV (some cycles)
Size
~MBs per cycle component
License
Public domain
Updated
Biennial cycles

World Health Organization Direct download

WHO Global Health Observatory

WHO’s repository of health indicators for its member states — life expectancy, disease burden, immunization coverage, health-system metrics — via an open OData API and CSV export.

Formats
OData API (JSON) · CSV export
Size
~2k+ indicators × 190+ countries
License
CC BY-NC-SA 3.0 IGO
Updated
Rolling

Payments & policy

U.S. Centers for Medicare & Medicaid Services Direct download

CMS Open Payments

Every payment and transfer of value from drug and device companies to U.S. physicians and teaching hospitals, reported under the Sunshine Act — searchable and downloadable in full.

Transparency as a CSV: you can look up any U.S. physician. Yes, including me.

Formats
CSV (bulk, by program year) · API
Size
~GBs per program year
License
Public domain
Updated
Annually (with refreshes)

U.S. Centers for Medicare & Medicaid Services Direct download

data.CMS.gov (Medicare utilization & providers)

CMS program data: Medicare utilization and payment by provider and service, hospital cost reports, provider enrollment, and more — the raw material of U.S. health-policy analysis.

Formats
CSV · API (JSON)
Size
~MBs to ~GBs per dataset
License
Public domain
Updated
Dataset-dependent

Literature

U.S. National Library of Medicine Direct download

PubMed/MEDLINE annual baseline

The complete PubMed citation database — 38M+ biomedical citations and abstracts with MeSH indexing — released annually as bulk XML, with daily update files.

All of biomedicine’s abstracts in one download. Bring a real disk.

Formats
XML (gzipped, FTP/HTTPS)
Size
~40+ GB compressed
License
Free to download; NLM terms apply to some abstract text
Updated
Annual baseline + daily updates

Clinical records

MIT Laboratory for Computational Physiology Free, but credentialed (training + data-use agreement)

PhysioNet / MIMIC-IV

De-identified electronic health records from real ICU and ED admissions at Beth Israel Deaconess — labs, vitals, medications, notes. The workhorse dataset of clinical machine-learning research.

Free, but you must pass a human-subjects course first. The data is worth the homework.

Formats
CSV · BigQuery
Size
~tens of GBs
License
PhysioNet Credentialed Health Data License (free; DUA + CITI training required)
Updated
Versioned releases

Bioactivity & molecules

EMBL — European Bioinformatics Institute Direct download

ChEMBL

A manually curated database of bioactive molecules with drug-like properties: 2.4M+ compounds, 20M+ activity measurements against biological targets, downloadable as a complete database.

An entire medicinal-chemistry department’s memory, as a single SQLite file.

Formats
SQLite / PostgreSQL / MySQL dumps · SDF · web API
Size
~GBs
License
CC BY-SA 3.0
Updated
~2 releases/year

This library is a personal, hand-maintained list of public resources. Each dataset belongs to and is licensed by its maintainer — check the license before you build on one. Listing here is not an endorsement by any of these organizations, and nothing on this page is medical advice.